Peiker G, Müller B, Nöschel H, Bonow A
Pharmazie. 1979 Apr;34(4):244-6.
After oral administration of 0.4 g of methaqualone to pregnant and non-pregnant women, the authors stated that the half-life of this drug was significantly reduced during the last trimester of pregnancy. The two experimental groups showed no significant differences in the volume of distribution and the fictitious initial concentration. The commonly used therapeutical dosages are not likely to produce increased blood levels during normal pregnancy.
在给孕妇和非孕妇口服0.4克甲喹酮后，作者指出，在妊娠晚期该药物的半衰期显著缩短。两个实验组在分布容积和虚拟初始浓度方面无显著差异。常用治疗剂量在正常妊娠期间不太可能导致血药浓度升高。
