Angelin B, Einarsson K, Ewerth S, Leijd B
Scand J Gastroenterol. 1980;15(7):849-52. doi: 10.3109/00365528009181540.
Fasting duodenal bile was collected under standardized conditions in 10 male patients with stable portal cirrhosis of the liver and in 12 healthy male controls matched for age, body weight, and serum lipid levels. The proportion of cholesterol, expressed as molar percentage of total biliary lipids, was lower in patients with cirrhosis than in controls (4.6 +/- 0.6 versus 6.4 +/- 0.4 molar %, mean +/- S.E.M.; P less than 0.025), whereas the proportions of bile acids and phospholipids were similar in the two groups. The cholesterol saturation of bile was lower in cirrhotic patients (68 +/- 8%) than in controls (94 +/- 7%; P less than 0.025). The contribution of deoxycholic acid to total bile acids was diminished in cirrhosis and that of chenodeoxycholic acid slightly increased. The results suggest that, in spite of the disturbances of bile acid metabolism generally seen in cirrhosis, such patients are not prone to develop cholesterol gallstones.
在标准化条件下，收集了10例稳定期门静脉性肝硬化男性患者以及12例年龄、体重和血脂水平相匹配的健康男性对照者的空腹十二指肠胆汁。以总胆汁脂质的摩尔百分比表示的胆固醇比例，肝硬化患者低于对照组（4.6±0.6对6.4±0.4摩尔%，均值±标准误；P<0.025），而两组中胆汁酸和磷脂的比例相似。肝硬化患者胆汁的胆固醇饱和度低于对照组（68±8%对94±7%；P<0.025）。肝硬化时脱氧胆酸对总胆汁酸的贡献减少，鹅去氧胆酸的贡献略有增加。结果表明，尽管肝硬化患者通常存在胆汁酸代谢紊乱，但此类患者不易发生胆固醇胆结石。
