拮抗大鼠对抗利尿激素的抗利尿反应的加压素类似物。
Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone.
作者信息
Sawyer W H, Pang P K, Seto J, McEnroe M, Lammek B, Manning M
出版信息
Science. 1981 Apr 3;212(4490):49-51. doi: 10.1126/science.7209515.
PMID:7209515
Abstract
Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.
摘要
血管加压素（抗利尿激素）的四种新型合成类似物可拮抗麻醉状态下、水负荷大鼠对静脉注射血管加压素的抗利尿反应。当给清醒大鼠腹腔注射这些类似物时，它们还会引起类似尿崩症的利尿作用。这类拮抗剂可能在药理学和治疗学上都有用处。
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