天然存在的诱变剂槲皮素、前诱变剂芦丁和紫杉叶素的新代谢产物。 - Suppr

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New metabolites of the naturally-occurring mutagen, quercetin, the pro-mutagen, rutin and of taxifolin.

作者信息

Brown S, Griffiths L A

出版信息

Experientia. 1983 Feb 15;39(2):198-200. doi: 10.1007/BF01958898.

DOI:10.1007/BF01958898

PMID:6832297

Abstract

摘要

相似文献

New metabolites of the naturally-occurring mutagen, quercetin, the pro-mutagen, rutin and of taxifolin.天然存在的诱变剂槲皮素、前诱变剂芦丁和紫杉叶素的新代谢产物。

Experientia. 1983 Feb 15;39(2):198-200. doi: 10.1007/BF01958898.

Effect of bile acids on formation of the mutagen, quercetin, from two flavonol glycoside precursors by human gut bacterial preparations.胆汁酸对人体肠道细菌制剂从两种黄酮醇糖苷前体形成诱变剂槲皮素的影响。

Mutat Res. 1985 Mar;155(3):99-104. doi: 10.1016/0165-1218(85)90125-9.

Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin.喂食含芦丁或槲皮素日粮的大鼠血浆中的槲皮素代谢产物。

J Nutr. 1995 Jul;125(7):1911-22. doi: 10.1093/jn/125.7.1911.

Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS.采用 UPLC-Q-TOF/MS 鉴定人肠道细菌产生的芦丁糖基化代谢产物。

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100. doi: 10.1016/j.jchromb.2012.04.024. Epub 2012 Apr 25.

Biotransformation of flavonols and taxifolin in hepatocyte in vitro systems as determined by liquid chromatography with various stationary phases and electrospray ionization-quadrupole time-of-flight mass spectrometry.采用多种固定相和电喷雾电离-四极杆飞行时间质谱法测定肝细胞体外体系中类黄酮和taxifolin 的生物转化。

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:109-15. doi: 10.1016/j.jchromb.2012.05.009. Epub 2012 May 14.

Interaction of flavonoid compounds with contractile proteins of skeletal muscle.类黄酮化合物与骨骼肌收缩蛋白的相互作用。

Gen Physiol Biophys. 1988 Apr;7(2):165-75.

Activation of rutin by human oral bacterial isolates to the carcinogen-mutagen quercetin.人源口腔细菌分离株将芦丁激活为致癌物-诱变剂槲皮素。

Arch Oral Biol. 1983;28(7):583-90. doi: 10.1016/0003-9969(83)90005-5.

Urinary and faecal mutagenicity in Sprague-Dawley rats dosed with the food mutagens quercetin and rutin.给斯普拉格-道利大鼠喂食诱变剂槲皮素和芦丁后其尿液和粪便的诱变性

Food Chem Toxicol. 1987 Jan;25(1):9-15. doi: 10.1016/0278-6915(87)90301-2.

Degradation of quercetin and luteolin by Eubacterium ramulus.纤细真杆菌对槲皮素和木犀草素的降解作用

Appl Environ Microbiol. 2001 Dec;67(12):5558-67. doi: 10.1128/AEM.67.12.5558-5567.2001.

Quercetin, but not its glycosides, is absorbed from the rat stomach.槲皮素可从大鼠胃中吸收，但其糖苷则不能。

J Agric Food Chem. 2002 Jan 30;50(3):618-21. doi: 10.1021/jf010919h.

引用本文的文献

Scientific Opinion on taxifolin-rich extract from Dahurian Larch ().关于兴安落叶松富含紫杉叶素提取物的科学意见。（原文括号内内容缺失，翻译可能不太完整）

EFSA J. 2017 Feb 14;15(2):e04682. doi: 10.2903/j.efsa.2017.4682. eCollection 2017 Feb.

An effective biphase system accelerates hesperidinase-catalyzed conversion of rutin to isoquercitrin.一种有效的双相系统可加速橙皮苷酶催化芦丁向异槲皮苷的转化。

Sci Rep. 2015 Mar 3;5:8682. doi: 10.1038/srep08682.

Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans.人体肠道拟杆菌菌株对膳食类黄酮糖苷的水解作用。

Biochem J. 1987 Dec 15;248(3):953-6. doi: 10.1042/bj2480953.

本文引用的文献

Identification of the major biliary metabolite of (+)-catechin in the rat.大鼠体内（+）-儿茶素主要胆汁代谢物的鉴定

Xenobiotica. 1980 Dec;10(12):905-11. doi: 10.3109/00498258009033824.

Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora.粪酶：肠道菌群将膳食糖苷激活为诱变剂的模型。

Proc Natl Acad Sci U S A. 1980 Aug;77(8):4961-5. doi: 10.1073/pnas.77.8.4961.

3'-O-methyl-(+)-catechin glucuronide and 3'-O-methyl-(+)-catechin sulphate: new urinary metabolites of (+)-catechin in the rat and the marmoset.3'-O-甲基-(+)-儿茶素葡萄糖醛酸苷和3'-O-甲基-(+)-儿茶素硫酸盐：大鼠和狨猴体内(+)-儿茶素的新型尿液代谢产物。

Experientia. 1982 May 15;38(5):538-40. doi: 10.1007/BF02327037.

The metabolism and excretion of 3-O-methyl-(+)-catechin in the rat, mouse, and marmoset.3 - O - 甲基 -（+）- 儿茶素在大鼠、小鼠和狨猴体内的代谢与排泄。

Drug Metab Dispos. 1981 Jan-Feb;9(1):54-9.

Studies on flavonoid metabolism. Identification of the metabolities of (+)-catechin in rat urine.黄酮类化合物代谢研究。大鼠尿液中（+）-儿茶素代谢产物的鉴定。

Biochem J. 1964 Jul;92(1):173-9. doi: 10.1042/bj0920173.

Metabolism of the hydroxyethylrutosides. Biliary and urinary excretion of 3',4',5-(hydroxyethyl- 14 C), 7-tetra-O-( -hydroxyethyl)-rutoside in rats and monkeys after parenteral administration.羟乙基芦丁糖苷的代谢。大鼠和猴经肠胃外给药后3',4',5-(羟乙基- 14 C)，7-四-O-( -羟乙基)-芦丁糖苷的胆汁和尿液排泄情况。

Xenobiotica. 1972 Nov;2(6):575-86. doi: 10.3109/00498257209111085.

The bilary excretion of flavanones in the rat.大鼠中黄烷酮的胆汁排泄

Xenobiotica. 1979 Aug;9(8):491-501. doi: 10.3109/00498257909087263.

Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test: activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources.植物黄酮醇在沙门氏菌/哺乳动物微粒体试验中的致突变性：大鼠盲肠细菌及其他来源的混合糖苷酶对黄酮醇糖苷的激活作用

Mutat Res. 1979 Mar;66(3):223-40. doi: 10.1016/0165-1218(79)90083-1.

Mutagenic activity of quercetin and related compounds.槲皮素及相关化合物的诱变活性。

Science. 1977 Aug 5;197(4303):577-8. doi: 10.1126/science.327550.

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