[慢性肝炎患者中甲型肝炎病毒和乙肝核心抗体的发生率]

[Incidence of HAV and HBc antibodies in patients with chronic hepatitis].

作者信息

Tanno H, Fay O, Roncoroni M, Galimberti B, Palazzi J

出版信息

Acta Gastroenterol Latinoam. 1980;10(2):105-11.

Abstract

156 patients with chronic hepatitis were studied in Rosario, Argentina. 98 patients were HBsAg positive (group I) and 58 patients were negative (group II). 209 normal volunteer blood donors served as controls (group III). In all cases the presence of anti-HAV was sought by RIA and was found in 92% of cases in group I, 91% in group II and 82% in group II patients. In groups II and III we also determined the presence of anti-HBcAg by RIA being positive in 65% and 15% respectively (p less than 0.01). There were no differences related to sex, age and type of chronic hepatitis. We conclude, firstly that the percentage of anti-HAV is similar in chronic hepatitis and healthy controls; secondly, that 65% of patients with HBsAg negative chronic hepatitis have evidence of virus B infection demonstrated by the presence of anti-HBcAg; finally we remark the greater sensitivity of RIA over hemmagglutination for the detection of anti-HBcAg.

摘要

在阿根廷罗萨里奥对156例慢性肝炎患者进行了研究。98例患者HBsAg呈阳性（第一组），58例患者呈阴性（第二组）。209名正常志愿献血者作为对照（第三组）。在所有病例中，通过放射免疫分析法检测抗甲型肝炎病毒，结果发现第一组92%的病例、第二组91%的病例以及第三组82%的病例中存在抗甲型肝炎病毒。在第二组和第三组中，我们还通过放射免疫分析法检测抗乙型肝炎核心抗原，结果分别有65%和15%呈阳性（p小于0.01）。在性别、年龄和慢性肝炎类型方面没有差异。我们得出以下结论：第一，慢性肝炎患者和健康对照中抗甲型肝炎病毒的百分比相似；第二，65%的HBsAg阴性慢性肝炎患者有抗乙型肝炎核心抗原，证明存在乙型病毒感染；最后，我们指出放射免疫分析法在检测抗乙型肝炎核心抗原方面比血凝试验具有更高的灵敏度。