Melander A, Nordenskjöld E, Lundh B, Thorell J
Acta Med Scand. 1981;209(1-2):41-3. doi: 10.1111/j.0954-6820.1981.tb11549.x.
Serum concentrations of T4, T3, rT3 and TSH were determined before and after cessation of chronic smoking in healthy subjects. Their body weights were measured at the same intervals. Abstention from smoking was monitored through determination of CO content in blood. Cessation of smoking was accompanied by small reductions in serum T4 and rT3 and by a small rise in serum TSH. Serum T3 was not significantly altered. A minor rise in body weight was noticed. It is suggested that smoking promotes a modestly increased secretion of thyroid hormone, which is readjusted to normal following cessation of smoking. The assumed smoking-induced increase in thyroid hormone secretion is apparently not mediated by enhanced TSH secretion but by some other factor, e.g. the sympathetic nervous system. The hormonal changes might contribute to the increase in body weight frequently seen after cessation of smoking.
在健康受试者中，测定了慢性吸烟停止前后血清中T4、T3、反式T3（rT3）和促甲状腺激素（TSH）的浓度。在相同的时间间隔测量他们的体重。通过测定血液中的一氧化碳（CO）含量来监测戒烟情况。戒烟伴随着血清T4和rT3的小幅下降以及血清TSH的小幅上升。血清T3没有显著变化。体重有轻微增加。有人认为，吸烟会促进甲状腺激素分泌适度增加，戒烟后甲状腺激素分泌会重新调整至正常水平。假定的吸烟引起的甲状腺激素分泌增加显然不是由TSH分泌增加介导的，而是由其他一些因素介导的，例如交感神经系统。这些激素变化可能导致戒烟后常见的体重增加。
