Lubin J R, Loewenstein J I, Frederick A R
Am J Ophthalmol. 1981 Mar;91(3):332-41. doi: 10.1016/0002-9394(81)90286-5.
The Vogt-Koyanagi-Harada syndrome includes inflammation of the uveal tract, retina, and meninges. Integumentary and auditory signs are common. Neurologic involvement has been reported. We studied two patients who manifested many of the varied clinical signs of Vogt-Koyanagi-Harada syndrome, but who also showed focal neurologic involvement, including acute transverse myelitis and ciliary ganglionitis. Both patients responded well to corticosteroid therapy. The findings in these patients and the results of previous studies suggest that Vogt-Koyanagi-Harada syndrome is a cell-mediated autoimmune disorder in which a component of myelin acts as an inciting antigen.
伏格特-小柳-原田综合征包括葡萄膜、视网膜和脑膜的炎症。皮肤和听觉症状很常见。也有神经系统受累的报道。我们研究了两名患者，他们表现出伏格特-小柳-原田综合征的许多不同临床症状，但也有局灶性神经系统受累，包括急性横贯性脊髓炎和睫状神经节炎。两名患者对皮质类固醇治疗反应良好。这些患者的发现以及先前研究的结果表明，伏格特-小柳-原田综合征是一种细胞介导的自身免疫性疾病，其中髓磷脂的一个成分作为激发抗原。
