Kramer L D, Hardy J L, Presser S B, Houk E J
Am J Trop Med Hyg. 1981 Jan;30(1):190-7. doi: 10.4269/ajtmh.1981.30.190.
There are two dose-dependent barriers to the transmission of western equine encephalomyelitis virus in infected female Culex tarsalis. In the first, virus multiplies in the mesenteron, but does not invade other tissues regardless of the length of extrinsic incubation. We call this the "mesenteronal escape" barrier. In some mosquitoes virus escapes from the infected mesenteron but a second barrier prevents infection of the salivary glands and perhaps neural tissues. We designate this the "salivary gland infection" barrier. The effectiveness of the second barrier decreases with time but still is evident after 21 days of extrinsic incubation. The distribution of virus in the tissues of nontransmitting females with either of these barriers is described.
在感染西马脑炎病毒的雌性致倦库蚊中，存在两种剂量依赖性的病毒传播障碍。首先，病毒在中肠内增殖，但无论外在潜伏期长短，都不会侵入其他组织。我们将此称为“中肠逃逸”障碍。在一些蚊子中，病毒从受感染的中肠逃逸，但第二种障碍会阻止唾液腺甚至神经组织被感染。我们将此称为“唾液腺感染”障碍。第二种障碍的有效性会随时间降低，但在21天的外在潜伏期后仍然明显。本文描述了具有这两种障碍之一的非传播性雌蚊组织中病毒的分布情况。
