Hardy J L, Apperson G, Asman S M, Reeves W C
Am J Trop Med Hyg. 1978 Mar;27(2 Pt 1):313-21. doi: 10.4269/ajtmh.1978.27.313.
After prolonged selection, two hybrid strains of Culex tarsalis were evolved that were highly resistant to infection following ingestion of western equine encephalomyelitis virus. These strains were greater than 25,000-fold more resistant than the most susceptible parental strain when fed on viremic chicks. Resistance was associated with a mesenteronal barrier since both refractory and parental strains were equally susceptible to infection by intrathoracic inoculation. Susceptibility was dominant, possibly incompletely dominant, over resistance. Inheritance was probably polyfactorial but this could not be determined with certainty since a small proportion of individuals appeared to become infected by nongenetic mechanisms.
经过长期选育，培育出了两种尖音库蚊杂交品系，它们在摄入西部马脑炎病毒后对感染具有高度抗性。当以感染病毒的雏鸡为食时，这些品系的抗性比最易感的亲本品系高25000倍以上。抗性与肠系膜屏障有关，因为抗性品系和亲本品系经胸腔接种时对感染同样敏感。易感性对抗性呈显性，可能是不完全显性。遗传可能是多因子的，但由于一小部分个体似乎通过非遗传机制受到感染，所以无法确定。
