Krohg K, Jellum E
Anesthesiology. 1981 Apr;54(4):329-32. doi: 10.1097/00000542-198104000-00014.
The purpose of this study was to identify the metabolic pathway of 2-chloro-4-aminobenzoic acid (CABA), a primary metabolite of chloroprocaine. Urine was collected from 4 healthy, pregnant women following the epidural administration of 600 mg chloroprocaine. The urinary metabolites were extracted with ether and identified and quantitatively estimated with a gas chromatography--mass spectrometry instrument. The analysis showed that CABA is converted to N-acetyl-CABA and subsequently excreted in the urine.
本研究的目的是确定氯普鲁卡因的主要代谢产物2-氯-4-氨基苯甲酸（CABA）的代谢途径。在4名健康孕妇硬膜外给予600mg氯普鲁卡因后收集尿液。尿代谢产物用乙醚提取，并用气相色谱-质谱仪进行鉴定和定量评估。分析表明，CABA转化为N-乙酰基-CABA，随后经尿液排出。
