Hanno R, Needelman A, Eiferman R A, Callen J P
Arch Dermatol. 1981 Apr;117(4):203-7.
Studies of patients with systemic sarcoidosis have indicated that those patients with cutaneous lesions have a poorer prognosis with a greater incidence of symptomatic pulmonary and ocular sarcoidosis. We examined 18 patients who had biopsy-proved cutaneous sarcoidosis for evidence of systemic involvement. Of the 13 patients who had no history of previously documented sarcoidosis, six had no evidence of systemic disease on history and physical examination, chest roentgenogram, pulmonary function testing, ocular examination, skin testing, and baseline laboratory testing. The seven remaining patients had evidence of sarcoidosis in another organ system, but six of the seven were essentially asymptomatic and required no therapy. The poorer prognosis associated with cutaneous sarcoidal granulomas drawn from populations with proved systemic sarcoidosis does not seem to apply to generally healthy outpatients with skin lesions as the initial manifestation of their disease.
对系统性结节病患者的研究表明，有皮肤损害的患者预后较差，有症状的肺部和眼部结节病的发病率更高。我们检查了18例经活检证实为皮肤结节病的患者，以寻找全身受累的证据。在13例既往无结节病记录史的患者中，6例在病史、体格检查、胸部X线检查、肺功能测试、眼部检查、皮肤试验和基线实验室检查中均无全身疾病证据。其余7例患者在其他器官系统有结节病证据，但7例中有6例基本无症状，无需治疗。从已证实有系统性结节病的人群中得出的与皮肤结节性肉芽肿相关的较差预后，似乎不适用于以皮肤损害为疾病初始表现的一般健康门诊患者。
