Rosen Y, Amorosa J K, Moon S, Cohen J, Lyons H A
AJR Am J Roentgenol. 1977 Dec;129(6):1083-5. doi: 10.2214/ajr.129.6.1083.
Granulomas were found in the lungs of 21 consecutive patients with stage I sarcoidosis who underwent open lung biopsy. The extent of granulomatous disease and fibrosis was significantly less (P less than .05) than seen in open lung biopsies from larger groups of patients with stage II and stage III sarcoidosis. The results of this study support what had previously been widely suspected: that is, if sufficient lung tissue is studied microscopically, granulomas will be found in the lungs of all patients having sarcoidosis with mediastinal lymphadenopathy but not radiographically demonstrable lung abnormalities.
在21例接受开胸肺活检的I期结节病患者的肺中发现了肉芽肿。肉芽肿性疾病和纤维化的程度明显低于（P<0.05）在更大组的II期和III期结节病患者的开胸肺活检中所见。本研究结果支持了此前广泛怀疑的观点：也就是说，如果对足够的肺组织进行显微镜检查，在所有患有结节病且有纵隔淋巴结肿大但胸部X线检查无明显肺部异常的患者的肺中都能发现肉芽肿。
