地塞米松治疗高钠血症性脱水
Dexamethasone in the treatment of hypernatraemic dehydration.
作者信息
Haque K N
出版信息
Arch Dis Child. 1981 Mar;56(3):223-4. doi: 10.1136/adc.56.3.223.
Ninety infants with severe hypernatraemic dehydration (plasma sodium greater than 150 mmol/l) were studied. Most had had a convulsion before admission. They were allocated to two treatment groups. Both groups received intravenous plasma followed by slow intravenous rehydration and correction of acidosis. In addition, one group received intramuscular phenobarbitone, the other group received dexamethasone 0.3 mg by intramuscular injection every 6 hours for 48 hours. Fewer infants receiving dexamethasone had convulsions during treatment (18% compared with 52%), and fewer (18%) of them died than in the group who did not receive dexamethasone (40%). Dexamethasone may have a role in the management of hypernatraemic dehydration in infants.
对90例重度高钠血症脱水（血浆钠大于150 mmol/L）的婴儿进行了研究。大多数婴儿在入院前发生过惊厥。他们被分为两个治疗组。两组均先静脉输注血浆，随后缓慢静脉补液并纠正酸中毒。此外，一组接受肌肉注射苯巴比妥，另一组每6小时肌肉注射地塞米松0.3 mg，共48小时。接受地塞米松治疗的婴儿在治疗期间惊厥发作较少（18%，而未接受地塞米松治疗的婴儿为52%），且死亡的婴儿也较少（18%，未接受地塞米松治疗的婴儿为40%）。地塞米松可能在婴儿高钠血症脱水的治疗中发挥作用。
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