用癌胚抗原和碱性磷酸酶筛查结直肠癌肝转移
Screening for liver metastases from colorectal cancer with carcinoembryonic antigen and alkaline phosphatase.
作者信息
Tartter P I, Slater G, Gelernt I, Aufses A H
出版信息
Ann Surg. 1981 Mar;193(3):357-60. doi: 10.1097/00000658-198103000-00019.
Abstract
A sensitive and economic method of screening for liver metastases in patients with colorectal cancer was developed using serum alkaline phosphatase and carcinoembryonic antigen. The upper limit of normal for alkaline phosphatase and carcinoembryonic antigen did not represent the optimal levels for use in predicting liver metastases. However, with alkaline phosphatase greater than 135 I.U., and/or carcinoembryonic antigen greater than 10 ng/ml, sensitivity was 88%: 23 of 26 patients with liver metastases fulfilled either or both criteria. The false-positive rate was 12%. Liver scanning, alone, demonstrated metastases in only 69% of 35 patients with liver metastases. The combination of alkaline phosphatase and carcinoembryonic antigen can be used economically to screen for liver metastases, and to determine which patients should undergo a liver scan.
摘要
利用血清碱性磷酸酶和癌胚抗原，开发出一种用于筛查结直肠癌患者肝转移的灵敏且经济的方法。碱性磷酸酶和癌胚抗原的正常上限并非预测肝转移的最佳使用水平。然而，当碱性磷酸酶大于135国际单位，和/或癌胚抗原大于10纳克/毫升时，敏感度为88%：26例肝转移患者中有23例符合一项或两项标准。假阳性率为12%。仅肝脏扫描显示，35例肝转移患者中只有69%有转移。碱性磷酸酶和癌胚抗原联合使用可经济地用于筛查肝转移，并确定哪些患者应接受肝脏扫描。
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