血清酶和癌胚抗原对转移性结直肠癌早期诊断的贡献。
The contribution of serum enzymes and carcinoembryonic antigen to the early diagnosis of metastatic colorectal cancer.
作者信息
Cooper E H, Turner R, Steele L, Neville A M, Mackay A M
出版信息
Br J Cancer. 1975 Jan;31(1):111-7. doi: 10.1038/bjc.1975.13.
Abstract
The evolution of metastatic colorectal cancer in patients who have had surgical treatment for a primary lesion was studied in relation the progressive changes in the blood levels of carcinembryonic antigen (CEA), to gamma glutamyl transpeptidase (GGT) and routine liver function tests (LFTs). Involvement of the liver could ofter be reliably predicted many weeks in advance of clinical diagnosis while metastases to other sites were less likely to be detected early by this test. The association of the extent of disease with the patterns of biochemical changes is discussed with reference to several illustrative examples.
摘要
对已接受原发性病变手术治疗的转移性结直肠癌患者的病情演变进行了研究，研究内容涉及癌胚抗原（CEA）、γ-谷氨酰转肽酶（GGT）的血液水平以及常规肝功能检查（LFTs）的渐进性变化。在临床诊断前数周，通常能够可靠地预测肝脏是否受累，而通过该检测早期发现转移至其他部位的可能性较小。结合几个实例讨论了疾病程度与生化变化模式之间的关联。
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本文引用的文献
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[Leucine aminopeptidase (arylamidase) activity in the serum. Determination using leucine-p-nitroanilide as substrate].[血清中的亮氨酸氨基肽酶（芳基酰胺酶）活性。以亮氨酸 - 对硝基苯胺为底物进行测定]
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