Gómez P, Castillo R, Rábago M, Luna G, García-Alonso H
Arch Invest Med (Mex). 1980;11(4):477-90.
Protein pattern was studied using discontinuous polyacrylamide gel electrophoresis in 53 adenocarcinomas, 13 fibroadenomas and 66 samples of mammary tissue adjacent to neoplasias. Important differences were found in patterns of both types of neoplasias, the same as between malignant tissues and non neoplastic adjacent tissues. There seems to be a certain correlation between some protein pattern and NOS and lobular histological types. It was also observed that some protein patterns were more frequent in neoplasias with metastasis to axillary nodes and vascular invasion. On the other hand, there seems to be important correlation between some protein patterns and the presence of early tumoral activity after mastectomy that is present even in the absence of positive axillary nodes at the moment of surgery.
采用不连续聚丙烯酰胺凝胶电泳对53例腺癌、13例纤维腺瘤以及66例肿瘤旁乳腺组织样本的蛋白质图谱进行了研究。在这两种肿瘤类型的图谱中均发现了重要差异，恶性组织与肿瘤旁非肿瘤组织之间亦是如此。某些蛋白质图谱与一氧化氮合酶（NOS）及小叶组织学类型之间似乎存在一定相关性。还观察到，某些蛋白质图谱在伴有腋窝淋巴结转移和血管侵犯的肿瘤中更为常见。另一方面，某些蛋白质图谱与乳房切除术后早期肿瘤活性的存在之间似乎存在重要相关性，即使在手术时腋窝淋巴结无转移的情况下亦是如此。
