Seffner W, Pfützner H
Arch Exp Veterinarmed. 1980;34(6):817-26.
Macroscopic and histological findings, obtained from 60 udders, are described in this paper. The animals had been infected with mycoplasma bovis and slaughtered, after something between two and 21 days had elapsed from infection. The infections and, consequently, pathologico-anatomic and histological changes were found to expand rapidly over the infected quarter and, with only little time lag, across non-infected control quarters. Roughly one week from infection, the affected quarters appeared engorged, slightly enlarged, and of tough consistence, their cutting surfaces being nodular and of moderate grey-yellowish discoloration. The same quarters were clearly reduced in size, between two and three weeks after infection, and still of tough consistence, their cutting surfaces being light brown to brown-yellow and smooth. Pronounced degeneration of alveolar epithelium, exudation of neutrophilic granulocytes, differentiated in intensity, and intra-alveolar accumulation of strongly eosin-coloured homogenous substance were the histological findings recorded between four and nine days from infection. The same alterations, yet, less strongly pronounced, continued to be recordable from now reduced alveoli, between two and three weeks from infection. Lactating tissue had entirely vanished by that time. The general pattern then was characterised by extensive alveolar atrophy and inter-alveolar infiltration of plasma cells, lymphocytes, and histiocytes. These changes proved useful in diagnosis.
本文描述了从60个乳房获得的宏观和组织学发现。这些动物感染了牛支原体，在感染后两到二十一天之间被宰杀。发现感染以及由此产生的病理解剖和组织学变化在受感染的乳腺象限迅速扩展，并且仅稍有时间滞后就蔓延到未感染的对照象限。感染大约一周后，受影响的乳腺象限显得充血、略有肿大且质地坚韧，其切面呈结节状且有中度灰黄色变色。在感染后两到三周，相同的乳腺象限明显缩小，质地仍然坚韧，其切面呈浅棕色至棕黄色且光滑。感染后四到九天记录的组织学发现为肺泡上皮明显变性、嗜中性粒细胞渗出（强度不同）以及肺泡内强烈嗜酸性均质物质的积聚。然而，从感染后两到三周现在已经缩小的肺泡中仍可记录到相同的改变，但程度较轻。那时泌乳组织已完全消失。总体模式的特征是广泛的肺泡萎缩以及浆细胞、淋巴细胞和组织细胞的肺泡间浸润。这些变化被证明对诊断有用。
