van der Molen E J, Grootenhuis G
Tijdschr Diergeneeskd. 1979 Jul 15;104(14):suppl 126-33.
A field case of mastitis in cows, caused by Mycoplasma agalactiae var. bovis, formed the occasion to conduct an infection experiment. Five lactating heifers were infected in the udder at different times. The cows were slaughtered 2, 5, 7, 9 and 12 days p.i. and the pathological changes were studied. The investigation indicated that the pathological picture differed with time: in the acute stage, the inflammation was characterized by exudation of mostly eosinophils in the alveoli; later on, the mastitis was identified by an interstitial reaction with eosinophils and mononuclear cells, including plasma cells and lymphocytes; in the chronic stage, progressive fibroplasia around ductuli and alveoli, with hypertrophy of alveolar epithelium, was characteristic. The pathological findings are discussed.
由牛无乳支原体引起的奶牛乳腺炎现场病例，为进行感染实验提供了契机。五头泌乳小母牛在不同时间感染乳房。感染后2、5、7、9和12天宰杀奶牛，并研究病理变化。调查表明，病理表现随时间而异：急性期，炎症特征为肺泡内主要是嗜酸性粒细胞渗出；随后，乳腺炎表现为嗜酸性粒细胞和单核细胞（包括浆细胞和淋巴细胞）的间质反应；慢性期，特征是小叶间导管和肺泡周围进行性纤维组织增生，伴有肺泡上皮肥大。对病理结果进行了讨论。
