Wood J R, Anderson R L
Arch Ophthalmol. 1981 Mar;99(3):460-3. doi: 10.1001/archopht.1981.03930010462014.
We describe 70 patients who underwent cryosurgery to the lids during a two-year period. Of the 58 receiving adequate follow-up, approximately one fourth had complications thought to be directly caused by cryosurgery. These include visual loss, lid notching, corneal ulcer, acceleration of symblepharon formation, xerosis, cellulitis, activation of herpes zoster, skin depigmentation, and severe soft-tissue reaction. In addition, 9% of the lids showed possible induction of trichiasis in areas adjacent to treatment. More than two thirds of patients with conjunctival shrinkage or grafted or irradiated lids had adverse effects, with one case of permanent visual loss. Misdirected lashes were successfully eliminated with a single double freeze-thaw technique in 90% of lids treated. Cryosurgery for aberrant lashes and some benign lid lesions is the most effective method of therapy presently available, but one must be aware of its potential complications. It has a low complication rate in "normal" lids, but should be used with caution in patients with conjunctival shrinkage or in those with grafted and/or irradiated lids.
我们描述了70例在两年期间接受眼睑冷冻手术的患者。在58例接受充分随访的患者中，约四分之一出现了被认为是由冷冻手术直接引起的并发症。这些并发症包括视力丧失、眼睑切迹、角膜溃疡、睑球粘连形成加速、干燥症、蜂窝织炎、带状疱疹激活、皮肤色素脱失以及严重的软组织反应。此外，9%的眼睑在治疗区域附近显示出可能诱发倒睫。超过三分之二的结膜萎缩或接受移植或放疗的眼睑患者出现了不良反应，其中1例永久性视力丧失。在90%接受治疗的眼睑中，单次双冻融技术成功消除了误向的睫毛。冷冻手术治疗异常睫毛和一些良性眼睑病变是目前可用的最有效治疗方法，但必须意识到其潜在并发症。在“正常”眼睑中其并发症发生率较低，但对于结膜萎缩患者或接受移植和/或放疗的眼睑患者应谨慎使用。
