N-取代卟啉对原血红素铁裂解酶的抑制作用。抑制效应的结构要求。
Inhibition of protohaem ferro-lyase by N-substituted porphyrins. Structural requirements for the inhibitory effect.
作者信息
De Matteis F, Gibbs A H, Smith A G
出版信息
Biochem J. 1980 Sep 1;189(3):645-8. doi: 10.1042/bj1890645.
Abstract
N-Methyl mesoporphyrin was a powerful inhibitor of protohaem ferro-lyase in vitro, whereas N-ethyl mesoporphyrin and N-methyl coproporphyrin were not and neither was the newly described green pigment produced by giving rats ethylene. This suggests that the size of the substituent at a pyrrole nitrogen and also the number of carboxylic acid side chains of the substituted porphyrin are important for the inhibitory effect. Evidence that N-methyl mesoporphyrin inhibited the enzyme, whereas the ethylene-derived pigment did not, was also obtained in vivo.
摘要
N-甲基中卟啉在体外是原血红素铁裂解酶的强效抑制剂，而N-乙基中卟啉和N-甲基粪卟啉则不是，给大鼠注射乙烯产生的新描述的绿色色素也不是。这表明吡咯氮上取代基的大小以及取代卟啉羧酸侧链的数量对抑制作用很重要。在体内也获得了N-甲基中卟啉抑制该酶而乙烯衍生色素不抑制该酶的证据。
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