3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁所致实验性卟啉症机制的研究。一种原卟啉亚铁裂解酶的卟啉样抑制剂的作用。
Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase.
作者信息
Tephly T R, Gibbs A H, De Matteis F
出版信息
Biochem J. 1979 Apr 15;180(1):241-4. doi: 10.1042/bj1800241.
Abstract
A green porphyrin-like pigment with inhibitory properties towards protohaem ferro-lyase activity was isolated from the livers of mice and rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Mice, which are more sensitive to the porphyrogenic properties of the drug, produce more inhibitor. The non-porphyrogenic analogue 3,5-diethoxycarbonylcollidine does not cause accumulation of the pigment in the liver. The inhibitory substance is present in control liver at low but measurable concentrations.
摘要
在用3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁处理后的小鼠和大鼠肝脏中，分离出了一种对原卟啉亚铁裂解酶活性具有抑制特性的绿色卟啉样色素。对该药物的致卟啉特性更敏感的小鼠会产生更多的抑制剂。非致卟啉类似物3,5 - 二乙氧羰基可力丁不会导致肝脏中色素的积累。对照肝脏中存在低浓度但可测量的抑制物质。
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1
2
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3
Effect of drugs on heme synthesis in the liver.药物对肝脏血红素合成的影响。
Metabolism. 1971 Feb;20(2):200-14. doi: 10.1016/0026-0495(71)90092-8.
4
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5
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