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3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁所致实验性卟啉症机制的研究。一种原卟啉亚铁裂解酶的卟啉样抑制剂的作用。

Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase.

作者信息

Tephly T R, Gibbs A H, De Matteis F

出版信息

Biochem J. 1979 Apr 15;180(1):241-4. doi: 10.1042/bj1800241.

DOI:10.1042/bj1800241
PMID:486100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161040/
Abstract

A green porphyrin-like pigment with inhibitory properties towards protohaem ferro-lyase activity was isolated from the livers of mice and rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Mice, which are more sensitive to the porphyrogenic properties of the drug, produce more inhibitor. The non-porphyrogenic analogue 3,5-diethoxycarbonylcollidine does not cause accumulation of the pigment in the liver. The inhibitory substance is present in control liver at low but measurable concentrations.

摘要

在用3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁处理后的小鼠和大鼠肝脏中，分离出了一种对原卟啉亚铁裂解酶活性具有抑制特性的绿色卟啉样色素。对该药物的致卟啉特性更敏感的小鼠会产生更多的抑制剂。非致卟啉类似物3,5 - 二乙氧羰基可力丁不会导致肝脏中色素的积累。对照肝脏中存在低浓度但可测量的抑制物质。

相似文献

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本文引用的文献

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Effects of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate on the metabolism of porphyrins and iron.二乙基-1,4-二氢-2,4,6-三甲基吡啶-3,5-二羧酸酯对卟啉和铁代谢的影响
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Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide.由致卟啉剂2-烯丙基-2-异丙基乙酰胺引起的大鼠肝脏血红素损失。
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Effect of 3,5-diethoxycarbonyl-1,4-dihydrocollidine on degradation of liver haem.
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Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Studies in rats and mice.3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁所致肝性卟啉病中肝脏卟啉 - 金属螯合酶活性降低。大鼠和小鼠研究。
Biochem J. 1973 Jul;134(3):717-27. doi: 10.1042/bj1340717.
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The structural organization of haem synthesis in rat liver mitochondria.大鼠肝脏线粒体中血红素合成的结构组织
Biochem J. 1969 Jul;113(3):507-14. doi: 10.1042/bj1130507.
8
Stimulation of the pathway of porphyrin synthesis in the liver of rats and mice by griseofulvin, 3,5-Diethoxycarbonyl-1,4-dihydrocollidine and related drugs: evidence for two basically different mechanisms.灰黄霉素、3,5-二乙氧羰基-1,4-二氢可力丁及相关药物对大鼠和小鼠肝脏卟啉合成途径的刺激作用：两种根本不同机制的证据
Biochem J. 1975 Jan;146(1):285-7. doi: 10.1042/bj1460285.
9
Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide.用2-烯丙基-2-异丙基乙酰胺处理的大鼠肝脏血红素降解为卟啉和氧化卟啉。
Biochem Soc Trans. 1976;4(2):297-8. doi: 10.1042/bst0040297.