茶碱和氨茶碱在人体中的比较药代动力学
Comparative pharmacokinetics of theophylline and aminophylline in man.
作者信息
Aslaksen A, Bakke O M, Vigander T
出版信息
Br J Clin Pharmacol. 1981 Mar;11(3):269-73. doi: 10.1111/j.1365-2125.1981.tb00533.x.
Abstract
1 The pharmacokinetics of theophylline and aminophylline was compared after oral administration and intravenous infusion. 2 Theophylline (250 mg) and aminophylline (390 mg) were taken orally by eight healthy volunteers in a randomized cross-over study. 3 In another cross-over study theophylline and aminophylline were administered intravenously to six healthy volunteers at a dose corresponding to 5 mg/kg pure theophylline. 4 The protein binding of the theophylline in serum collected during the intravenous study was studied by ultrafiltration. The serum concentration of theophylline was measured by high pressure liquid chromatography. 5 Almost identical concentration-time curves were found for theophylline and aminophylline in both of the studies. No significant difference was found in the pharmacokinetic parameters or protein binding with the two preparations.
摘要
- 比较了口服和静脉输注后茶碱和氨茶碱的药代动力学。2. 在一项随机交叉研究中，8名健康志愿者口服了250毫克茶碱和390毫克氨茶碱。3. 在另一项交叉研究中，以相当于5毫克/千克纯茶碱的剂量，对6名健康志愿者静脉注射了茶碱和氨茶碱。4. 通过超滤研究了静脉注射研究期间收集的血清中茶碱的蛋白结合情况。用高压液相色谱法测定血清中茶碱的浓度。5. 在两项研究中，茶碱和氨茶碱的浓度-时间曲线几乎相同。两种制剂在药代动力学参数或蛋白结合方面未发现显著差异。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Ethylenediamine contact dermatitis.乙二胺接触性皮炎
Arch Dermatol. 1967 Sep;96(3):231-4.
3
Absolute bioavailability of oral theophylline.口服茶碱的绝对生物利用度。
Am J Hosp Pharm. 1977 May;34(5):525-7.
4
Theophylline disposition in patients with hepatic cirrhosis.肝硬化患者体内茶碱的处置情况。
N Engl J Med. 1977 Jun 30;296(26):1495-7. doi: 10.1056/NEJM197706302962603.
5
Micro-scale method for theophylline in body fluids by reversed-phase, high-pressure liquid chromatography.反相高压液相色谱法测定体液中茶碱的微量方法。
Clin Chem. 1977 Mar;23(3):599-601.
6
Use of a programmable hand-held calculator for clinical pharmacokinetics.可编程手持计算器在临床药代动力学中的应用。
Am J Hosp Pharm. 1977 Jan;34(1):70-5.
7
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8
Contact dermatitis attributed to ethylenediamine.乙二胺所致接触性皮炎
Br Med J. 1978 Feb 18;1(6110):415-6. doi: 10.1136/bmj.1.6110.415.
9
Comparative bioavailability of a microcrystalline theophylline tablet and uncoated aminophylline tablets.
Eur J Clin Pharmacol. 1979;16(6):417-21. doi: 10.1007/BF00568203.
10
Clinical and pharmacological observations on a new microcrystalline theophylline preparation.关于一种新型微晶茶碱制剂的临床与药理学观察
Scand J Respir Dis. 1979 Dec;60(6):358-66.
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