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[可被乙醇和2-萘酚沉淀的纤维蛋白原B可溶性纤维蛋白单体复合物的性质]

[Nature of fibrinogen B-soluble fibrin monomer complexes precipitable by ethanol and 2-naphthol].

作者信息

Zubairov D M, Litvinov R I

出版信息

Biokhimiia. 1980 Jun;45(6):1059-67.

PMID:7213845
Abstract

The molecular composition of fibrinogen B, which is formed after addition of 2-naphthol solution in ethanol to pathological blood plasma was studied. The precipitate was found to contain native fibrinogen as well as fibrin monomer possessing fibrinopeptides B. Some proteins similar to the molecular forms of cold-insoluble blood plasma globulin were revealed. The data obtained suggest that fibrinogen B represents soluble complexes of monomeric fibrin with fibrinogen and probably with cold-insoluble globulin. The mechanisms of formation of these complexes and their precipitation by ethanol and 2-naphthol are discussed.

摘要

研究了在病理血浆中加入乙醇中的2-萘酚溶液后形成的纤维蛋白原B的分子组成。发现沉淀物中含有天然纤维蛋白原以及具有纤维蛋白肽B的纤维蛋白单体。还发现了一些与冷不溶性血浆球蛋白分子形式相似的蛋白质。所得数据表明,纤维蛋白原B代表单体纤维蛋白与纤维蛋白原以及可能与冷不溶性球蛋白的可溶性复合物。讨论了这些复合物的形成机制以及它们被乙醇和2-萘酚沉淀的机制。

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