沙丁胺醇和异克舒令对妊娠绵羊子宫和脐血流的影响。

Effects of salbutamol and isoxsuprine on uterine and umbilical blood flow in pregnant sheep.

作者信息

Ehrenkranz R A, Hamilton L A, Brennan S C, Oakes G K, Walker A M, Chez R A

出版信息

Am J Obstet Gynecol. 1977 Jun 1;128(3):287-93. doi: 10.1016/0002-9378(77)90623-8.

Abstract

The effects of salbutamol and isoxsuprine upon uterine artery blood flow (UtBF) and umbilical vein blood flow (UmBF) were investigated in near-term, nonlaboring chronic sheep preparations. During both intravenous salbutamol and isoxsuprine infusions to the ewe, UtBF and mean maternal arterial pressure decreased significantly. Also, dose-related maternal tachycardia, hyperglycemia, and relative acidemia occurred. There were no significant changes in UmBF, mean fetal arterial pressure, or fetal heart rate (FHR) during salbutamol infusions, but UmBF and FHR increased during isoxsuprine infusions. During the 120 minute postinfusion recovery period, UtBF rose significantly after the salbutamol infusions but not after the isoxsupine infusions. The effects and structure-activity relationship of these two drugs are comparable to those of ritodrine and fenoterol, two other beta-adrenergic agonists.

摘要

在接近足月、未临产的慢性绵羊实验模型中，研究了沙丁胺醇和异克舒令对子宫动脉血流（UtBF）和脐静脉血流（UmBF）的影响。在向母羊静脉输注沙丁胺醇和异克舒令的过程中，UtBF和母体平均动脉压显著降低。此外，出现了与剂量相关的母体心动过速、高血糖和相对性酸血症。在输注沙丁胺醇期间，UmBF、胎儿平均动脉压或胎儿心率（FHR）无显著变化，但在输注异克舒令期间，UmBF和FHR升高。在输注后120分钟的恢复期，输注沙丁胺醇后UtBF显著升高，但输注异克舒令后未升高。这两种药物的作用及构效关系与另外两种β-肾上腺素能激动剂利托君和非诺特罗相似。