Birembaut P, Gaillard D, Arnaudies J, Adnet J J, Labat-Robert J, Robert L
Bull Assoc Anat (Nancy). 1980 Sep;64(186):349-65.
Distribution of fibronectin (FN), a major glycoproteic component of extracellular matrix was studied by an indirect immuno-fluorescence technique using a rabbit anti-FN serum on frozen sections of fresh human tissues. In the extracellular matrix, FN is localized in epithelial and glandular basement membranes (bronchial, digestive, urothelial, prostatic, thyroid and mammary glands). FN is also visualized in vascular basement membranes and pulmonary alveolar basal laminae. In lymphoid tissues. In the liver and adrenal cortex, FN has the same distribution as reticulin fibers. In the kidney, glomerular mesangium in labeled. There are also pericellular labelings on fibroblastic and muscular cell surfaces. Epithelial cells of the mammary gland show a pericellular positive staining. FN is principally involved in cell orientation and in cell extra-cellular matrix interactions.
利用兔抗纤连蛋白（FN）血清，采用间接免疫荧光技术，在新鲜人体组织冰冻切片上研究了细胞外基质的主要糖蛋白成分纤连蛋白（FN）的分布。在细胞外基质中，FN定位于上皮和腺基底膜（支气管、消化道、尿路上皮、前列腺、甲状腺和乳腺）。在血管基底膜和肺泡基底层也可见FN。在淋巴组织中。在肝脏和肾上腺皮质，FN与网状纤维分布相同。在肾脏中，肾小球系膜被标记。在成纤维细胞和肌肉细胞表面也有细胞周围标记。乳腺上皮细胞呈现细胞周围阳性染色。FN主要参与细胞定向和细胞与细胞外基质的相互作用。
