苄丝肼（Ro4 - 4602）对大鼠松果体和下丘脑吲哚胺浓度的差异影响。
Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus.
作者信息
Arendt J, Ho A K, Laud C, Marston A, Nohria V, Smith J A, Symons A M
出版信息
Br J Pharmacol. 1981 Feb;72(2):257-62. doi: 10.1111/j.1476-5381.1981.tb09122.x.
Abstract
1 Low doses (50 and 80 mg/kg) of benserazide (Ro4-4602), an aromatic amino acid decarboxylase inhibitor, markedly reduced 5-hydroxytryptamine and melatonin in the rat pineal gland without affecting hypothalamic 5-hydroxytryptamine. 2 This differential effect shows that inhibition of the pineal gland decarboxylase activity is possible, and confirms that the rat pineal gland is accessible to peripherally acting agents.
摘要
- 低剂量（50和80毫克/千克）的苄丝肼（Ro4-4602），一种芳香族氨基酸脱羧酶抑制剂，可显著降低大鼠松果体中的5-羟色胺和褪黑素水平，而不影响下丘脑的5-羟色胺。2. 这种差异效应表明抑制松果体脱羧酶活性是可能的，并证实外周作用药物可作用于大鼠松果体。
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