Niwa T, Maeda K, Ohki T, Saito A, Kobayashi K
Clin Chim Acta. 1981 Feb 19;110(1):51-7. doi: 10.1016/0009-8981(81)90299-0.
(1) The concentrations of unconjugated and conjugated phenol, p-cresol, benzyl alcohol, catechol, hydroquinone, homocatechol, and 2-methoxyresorcinol in uremic serum were determined using a mass fragmentographic method. Concentrations of all phenols in uremic serum were higher than in normal serum. Conjugated phenols existed mainly as sulfate esters. (2) The concentration of unconjugated phenol in uremic serum correlated with those of serum creatinine and urea, but not with the hematocrit value. Patients with the highest concentration of unconjugated phenol suffered from cerebral disorders, coma or lethargy, and hemorrhagic tendencies. Unconjugated phenol was detected in normal serum at a concentration of 0.86 +/- 0.63 mumol/l (mean +/- S.D., n = 10). (3) The concentration of unconjugated p-cresol in uremic serum did not correlate with those of serum creatinine, urea and the hematocrit value. (4) The concentrations of unconjugated and conjugated hydroquinone in uremic serum correlated with those of serum creatinine and urea. (5) 2-Methoxyresorcinol was first detected mainly as sulfate ester in uremic serum at a concentration of 19 +/- 9.0 mumol/l (mean +/- S.D,. n = 17). (6) The daily excretion of eight unconjugated phenols into normal urine was determined.
(1) 采用质量碎片分析法测定了尿毒症血清中未结合和结合态的苯酚、对甲酚、苯甲醇、儿茶酚、对苯二酚、高儿茶酚和2-甲氧基间苯二酚的浓度。尿毒症血清中所有酚类的浓度均高于正常血清。结合态酚类主要以硫酸酯的形式存在。(2) 尿毒症血清中未结合苯酚的浓度与血清肌酐和尿素的浓度相关，但与血细胞比容值无关。未结合苯酚浓度最高的患者患有脑部疾病、昏迷或嗜睡以及出血倾向。正常血清中未结合苯酚的检测浓度为0.86±0.63μmol/l（平均值±标准差，n = 10）。(3) 尿毒症血清中未结合对甲酚的浓度与血清肌酐、尿素和血细胞比容值均无关。(4) 尿毒症血清中未结合和结合态对苯二酚的浓度与血清肌酐和尿素的浓度相关。(5) 首次在尿毒症血清中检测到2-甲氧基间苯二酚，主要以硫酸酯的形式存在，浓度为19±9.0μmol/l（平均值±标准差，n = 17）。(6) 测定了八种未结合酚类物质在正常尿液中的每日排泄量。
