Niwa T, Ise M, Miyazaki T, Meada K
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Nephron. 1993;65(1):82-7. doi: 10.1159/000187446.
Serum p-cresol and phenol are markedly accumulated in uremic patients. To determine if an oral sorbent (AST-120) can decrease their serum concentrations in the uremic state, an oral sorbent was administered to experimental nephrectomized uremic rats. In uremic rats fed with oral sorbent, the serum concentration and the urinary excretion of p-cresol were markedly and significantly lower than those in control uremic rats, while those of phenol tended to be low in the uremic rats with oral sorbent as compared with control uremic rats. The concentrations of serum creatinine and blood urea nitrogen were significantly decreased in the uremic rats with oral sorbent. These findings demonstrate that oral sorbent adsorbs especially p-cresol in the intestine and prevents the accumulation of p-cresol in the serum of uremic rats.
血清对甲酚和苯酚在尿毒症患者体内显著蓄积。为了确定口服吸附剂（AST - 120）是否能降低尿毒症状态下它们的血清浓度，将口服吸附剂给予实验性肾切除的尿毒症大鼠。在喂食口服吸附剂的尿毒症大鼠中，对甲酚的血清浓度和尿排泄量明显且显著低于对照尿毒症大鼠，而与对照尿毒症大鼠相比，口服吸附剂的尿毒症大鼠中苯酚的血清浓度和尿排泄量则趋于降低。口服吸附剂的尿毒症大鼠血清肌酐和血尿素氮浓度显著降低。这些发现表明，口服吸附剂在肠道中尤其吸附对甲酚，并防止对甲酚在尿毒症大鼠血清中蓄积。
