Critchley M, Gulliford P
Clin Radiol. 1980 Nov;31(6):717-22. doi: 10.1016/s0009-9260(80)80029-8.
Radionuclide imaging of the left ventricular blood pool provides a convenient non-invasive method of monitoring left ventricular function. Left ventricular function is characterised by the left ventricular curve which represents all phases of the cardiac cycle and is obtained by a multiple gated equilibrium method (MUGA). Volume curves were obtained over a minimum 1 1/2 h period in 15 normal subjects and in 20 thyrotoxic patients. Changes in left ventricular ejection fraction (LVEF), maximum ejection fraction rate and total electromechanical time interval were recorded from volume curve data. To assess the effect of pharmacological intervention, serial measurements of LVEF were made before and after 40 mg oral propranolol. In thyrotoxic patients, LVEF decreased by 17% of the initial value and in normal subjects by less than 10% following propranolol. This method can be extended to assess the effects of physiological or pharmacological intervention on left ventricular function in other disease states.
左心室血池的放射性核素成像提供了一种监测左心室功能的便捷非侵入性方法。左心室功能以左心室曲线为特征，该曲线代表心动周期的所有阶段，通过多门控平衡法（MUGA）获得。在15名正常受试者和20名甲状腺毒症患者中，在至少1.5小时的时间段内获取容积曲线。从容积曲线数据记录左心室射血分数（LVEF）、最大射血分数率和总机电时间间隔的变化。为了评估药物干预的效果，在口服40mg普萘洛尔前后对LVEF进行连续测量。在甲状腺毒症患者中，普萘洛尔治疗后LVEF下降了初始值的17%，而在正常受试者中下降不到10%。该方法可扩展用于评估生理或药物干预对其他疾病状态下左心室功能的影响。
