Galli G, Troncone L, Focacci C, Fedeli G, Anti M
Eur J Nucl Med. 1981 Mar;6(3):103-5. doi: 10.1007/BF00266419.
The authors, using 131I-Rose Bengal, determined the fractional transfer constants of a three-compartmental model in 30 patients divided into two groups (chronic active hepatitis and nonactive cirrhosis) on a histological basis. Other functional indexes were also taken into consideration. In nonactive cirrhosis, the results show a greater impairment of Rose Bengal transfer from plasma to liver. In chronic active hepatitis K32 (fractional transfer coefficient from the second to the third compartment) appears significantly lower than in nonactive cirrhosis. No significant differences have been found for K12 and K03. The best differentiation between the two groups (consistent with histological data in 29 of 30 cases) was obtained by grouping K21, retention index (RI) and SGOT in the discrimination function: L=4.88 K21-0.016RI+0.0034SGOT. The ratio K12/K21 seems meaningful for diagnostic purposes and in the evaluation of the hepatocellular damage in single cases.
作者使用131I-玫瑰红，在30例根据组织学分为两组（慢性活动性肝炎和非活动性肝硬化）的患者中，测定了三室模型的分数转移常数。还考虑了其他功能指标。在非活动性肝硬化中，结果显示玫瑰红从血浆向肝脏的转移受损更严重。在慢性活动性肝炎中，K32（从第二室到第三室的分数转移系数）明显低于非活动性肝硬化。K12和K03未发现显著差异。通过将K21、滞留指数（RI）和SGOT纳入判别函数进行分组，获得了两组之间的最佳区分（30例中有29例与组织学数据一致）：L = 4.88K21 - 0.016RI + 0.0034SGOT。K12/K21的比值似乎对诊断目的以及评估单例肝细胞损伤具有意义。
