Sturek J K, Sokoloski T D, Winsley W T, Stach P E
Am J Hosp Pharm. 1978 May;35(5):537-41.
The stability of nitroglycerin injection was studied over an eight-week period. Gas-liquid chromatographic assay and thin-layer chromatography were used to study the stability in relation to sorption by rubber and plastic (Viaflex), light and the effect of two diluents (5% dextrose in water and 0.9% sodium chloride for injection). More nitroglycerin was lost from vials with rubber closures, and the loss occurred at a faster rate when compared with nitroglycerin packaged in ampuls. There was no difference in the loss of nitroglycerin from injection packaged in ampuls when stored in the light or in the dark, or in the loss of nitroglycerin from two diluents, 5% dextrose in water and 0.9% sodium chloride for injection, packaged in glass bottles. A 70.4% greater loss of nitroglycerin occurred from Viaflex bags than from glass bottles. Loss of nitroglycerin in this study may have been characterized by reversible first-order kinetics.
在八周的时间内对硝酸甘油注射液的稳定性进行了研究。采用气液色谱分析法和薄层色谱法研究了其与橡胶和塑料（威盛适）的吸附作用、光照以及两种稀释剂（5%葡萄糖注射液和0.9%氯化钠注射液）的影响相关的稳定性。与安瓿包装的硝酸甘油相比，带有橡胶封盖的小瓶中损失的硝酸甘油更多，且损失速率更快。安瓿包装的注射液在光照或黑暗条件下储存时，硝酸甘油的损失没有差异，装在玻璃瓶中的两种稀释剂（5%葡萄糖注射液和0.9%氯化钠注射液）中硝酸甘油的损失也没有差异。与玻璃瓶相比，威盛适袋中硝酸甘油的损失要多70.4%。本研究中硝酸甘油的损失可能具有可逆一级动力学特征。
