Oddi括约肌旁路对进食和禁食的完整及胆囊切除犬胆汁酸代谢的影响。

Effects of sphincter of Oddi bypass on bile acid metabolism in fed and fasted intact and cholecystectomized dogs.

作者信息

Ramakrishnan V R, Beher W T, Lin G J, Stradnieks S, Samhouri F, Toledo-Pereyra L H, Block M A

出版信息

Digestion. 1981;21(3):143-50. doi: 10.1159/000198555.

DOI:10.1159/000198555

Abstract

The effects of cholecystectomy and sphincter of Oddi bypass on bile acid (BA) metabolism in dogs have been studied. Cholecystectomy and sphincter bypass decreased the BA pool half-life and increased the percent of taurodeoxycholic acid in the pool. A 48-hour fast had no effect on total BA pool size of intact and intact sphincter-of-Oddi-bypassed dogs but caused a marked decrease in cholecystectomized dogs. It was concluded that while the sphincter of Oddi is unnecessary to maintain bile acid pool size in fasting dogs, the gallbladder is. Alimentation is necessary to maintain pool size in cholecystectomized dogs.

摘要

已对胆囊切除术和Oddi括约肌旁路术对犬胆汁酸（BA）代谢的影响进行了研究。胆囊切除术和括约肌旁路术缩短了胆汁酸池的半衰期，并增加了胆汁酸池中牛磺去氧胆酸的百分比。禁食48小时对完整的犬以及Oddi括约肌旁路完整的犬的总胆汁酸池大小没有影响，但导致胆囊切除犬的总胆汁酸池大小显著降低。得出的结论是，虽然Oddi括约肌对于维持禁食犬的胆汁酸池大小并非必要，但胆囊是必要的。对于胆囊切除犬，进食对于维持胆汁酸池大小是必要的。