Schiemann D A, Devenish J A
Infect Immun. 1980 Aug;29(2):500-6. doi: 10.1128/iai.29.2.500-506.1980.
Virulence of human and environmental strains of Yersinia enterocolitica was evaluated by lethality in Mongolian gerbils and by the Serény test. The inducement of conjunctivitis in guinea pigs and lethality in gerbils after intraperitoneal administration was restricted to a few serotypes of Y. enterocolitica. Human strains of serotype O:8 were the most virulent, whereas strains of the common human serotype O:3 and most others were essentially avirulent. One virulent strain of serotype O:8 produced fatal infections within 7 days in four of five gerbils receiving 100 cells intraperitoneally. There was no observable difference in virulence between intraperitoneal and oral routes of administration, and upon death the infecting strain was found in high numbers in heart blood, lung, liver, and spleen. Virulence in both guinea pigs and gerbils was related to the presence of VW antigen determined by a nutritional requirement for calcium.
通过蒙古沙鼠的致死率以及塞雷尼试验评估了小肠结肠炎耶尔森菌的人源菌株和环境菌株的毒力。腹腔注射后，豚鼠结膜炎的诱发以及沙鼠的致死率仅限于小肠结肠炎耶尔森菌的少数血清型。血清型O:8的人源菌株毒力最强，而常见的人源血清型O:3菌株及大多数其他菌株基本无毒。一株血清型O:8的强毒株，在五只经腹腔注射100个菌细胞的沙鼠中，有四只在7天内产生了致命感染。腹腔注射和口服给药途径之间的毒力没有可观察到的差异，死亡时，在心血、肺、肝和脾中发现大量感染菌株。豚鼠和沙鼠的毒力都与VW抗原的存在有关，VW抗原由对钙的营养需求决定。
