Davis J K, Delozier K M, Asa D K, Minion F C, Cassell G H
Infect Immun. 1980 Aug;29(2):590-9. doi: 10.1128/iai.29.2.590-599.1980.
In comparison to syngeneic fibroblasts, alveolar macrophages collected from Fischer 344 rats demonstrated a significant ability to decrease the growth rate of cell-associated Mycoplasma pulmonis, even in the absence of specific actimycoplasmal antibodies. However, when exposed to thallium acetate (a cytotoxic heavy metal), macrophages supported growth of mycoplasmas almost as well as did untreated fibroblasts. This suggests an active antimycoplasmal process operative in untreated macrophages. In contrast, mouse alveolar macrophages were not capable of exerting an antimycoplasmal effect unless rabbit anti-M. pulmonis antibodies were present. Paradoxically, mouse anti-M. pulmonis antibodies did not promote this effect.
与同基因成纤维细胞相比，从Fischer 344大鼠收集的肺泡巨噬细胞表现出显著能力，即使在没有特异性抗支原体抗体的情况下，也能降低细胞相关的肺支原体生长速率。然而，当暴露于醋酸铊（一种细胞毒性重金属）时，巨噬细胞对支原体生长的支持程度几乎与未处理的成纤维细胞相同。这表明在未处理的巨噬细胞中存在一种活跃的抗支原体过程。相比之下，小鼠肺泡巨噬细胞除非存在兔抗肺支原体抗体，否则无法发挥抗支原体作用。矛盾的是，小鼠抗肺支原体抗体并不能促进这种作用。
