Howard C J, Taylor G
Yale J Biol Med. 1983 Sep-Dec;56(5-6):643-8.
Aspects of the interaction of certain mycoplasmas with macrophages and neutrophils in vivo and in vitro have been studied using two systems, one involving M. pulmonis in mice and the other involving M. bovis with bovine leucocytes. Studies with M. pulmonis indicated that the disappearance of viable organisms from the peritoneal cavity was not enhanced in SPF mice in which a peritoneal exudate rich in neutrophils had been induced. However, viable M. pulmonis organisms disappeared more rapidly from the peritoneal cavities with exudates containing increased numbers of macrophages. Experiments in vitro studied the opsonic effect of bovine IgG isotypes for bovine neutrophils and alveolar macrophages. Both IgG1 and IgG2 promoted killing of M. bovis by alveolar macrophages but IgG2 was more effective than IgG1 at promoting mycoplasma killing by neutrophils. Further studies in vitro indicated that certain bovine mycoplasma could inhibit killing of Escherichia coli by bovine neutrophils.
利用两个系统对某些支原体在体内和体外与巨噬细胞和中性粒细胞的相互作用进行了研究，一个系统涉及小鼠体内的肺炎支原体，另一个系统涉及牛支原体与牛白细胞。对肺炎支原体的研究表明，在已诱导出富含中性粒细胞的腹腔渗出液的无特定病原体（SPF）小鼠中，腹腔内活生物体的消失并未加速。然而，在含有数量增加的巨噬细胞的渗出液的腹腔中，活的肺炎支原体生物体消失得更快。体外实验研究了牛IgG同种型对牛中性粒细胞和肺泡巨噬细胞的调理作用。IgG1和IgG2均能促进肺泡巨噬细胞对牛支原体的杀伤，但在促进中性粒细胞对支原体的杀伤方面，IgG2比IgG1更有效。进一步的体外研究表明，某些牛支原体可抑制牛中性粒细胞对大肠杆菌的杀伤。
