通过主动特异性免疫疗法对豚鼠已建立的皮肤肿瘤移植和淋巴结转移进行消退。
Regression by active specific immunotherapy of established dermal tumor transplants and lymph node metastases in guinea pigs.
作者信息
Yarkoni E, Rapp H J
出版信息
Infect Immun. 1981 Jan;31(1):514-6. doi: 10.1128/iai.31.1.514-516.1981.
Abstract
Guinea pigs, each with an established, syngeneic dermal tumor (line-10) and microscopic lymph node metastasis, were treated by intradermal inoculation of living line-10 tumor cells admixed with emulsified heat-killed Mycobacterium bovis BCG cells. This treatment caused complete regression of established dermal tumors (about 10 mm in diameter) and prevented the growth of microscopic lymph node metastases in 25 of 39 treated animals (64%). All control animals treated by intradermal inoculation with heat-killed M. bovis BCG cells attached to oil droplets died with progressive dermal and lymphatic tumor growth.
摘要
豚鼠均已患有同基因皮肤肿瘤（10号线瘤株）并伴有微小的淋巴结转移，通过皮内接种与乳化热灭活牛型结核分枝杆菌卡介苗细胞混合的活10号线瘤株细胞进行治疗。这种治疗使已形成的皮肤肿瘤（直径约10毫米）完全消退，并在39只接受治疗的动物中有25只（64%）阻止了微小淋巴结转移灶的生长。所有通过皮内接种附着于油滴的热灭活牛型结核分枝杆菌卡介苗细胞进行治疗的对照动物均因皮肤和淋巴肿瘤的进行性生长而死亡。
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