趋化因子受体调节与细胞骨架结构
Chemotactic factor receptor modulation and cytoskeletal structures.
作者信息
Spilberg I, Mehta J
出版信息
Infect Immun. 1981 Apr;32(1):268-72. doi: 10.1128/iai.32.1.268-272.1981.
Abstract
The microfilament-disrupting agents cytochalasins A, B, and D were shown to impair the binding of the chemotactic factors [3H]formylmethionylleucylphenylalanine and 125 I-labeled crystal-induced chemotactic factor to their neutrophil receptor. Scatchard plot analysis revealed a decrease of the available binding sites in the cytochalasin B-treated cells. Cytochalasin B showed the same inhibitory profile on intact cells and on a membrane-rich preparation, suggesting that the effect was not dependent on an intact microfilament apparatus. The microtubule modifiers colchicine and vinblastine had no effect on the binding of the chemotactic factor to its cell receptors
摘要
微丝破坏剂细胞松弛素A、B和D已被证明会损害趋化因子[3H]甲酰甲硫氨酰亮氨酰苯丙氨酸和125I标记的晶体诱导趋化因子与其嗜中性粒细胞受体的结合。Scatchard图分析显示，经细胞松弛素B处理的细胞中可用结合位点减少。细胞松弛素B对完整细胞和富含膜的制剂表现出相同的抑制作用，表明该效应不依赖于完整的微丝装置。微管修饰剂秋水仙碱和长春花碱对趋化因子与其细胞受体的结合没有影响。
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本文引用的文献
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