葡萄球菌脓肿内产生的一种杀菌性脂质的特性研究。
Characterization of a bactericidal lipid developing within staphylococcal abscesses.
作者信息
Dye E S, Kapral F A
出版信息
Infect Immun. 1981 Apr;32(1):98-104. doi: 10.1128/iai.32.1.98-104.1981.
Abstract
Extraction of staphylococcal abscesses by the Folch procedure revealed that all of the staphylocidal activity was present in the lipid fraction. Further separation of the lipids indicated that the bactericidal activity resided in the free fatty acid pool. Lipids similarly extracted from mesenteric or epididymal fat tissue, either before of after activation, did not possess comparable activity. Myristic, palmitic, palmitoleic, linoleic, and oleic acids, as well as lysolecithin, also failed to exhibit the properties of the fatty acid fraction obtained from abscess homogenates. These findings suggest the staphylocidal fatty acid is not a common host lipid.
摘要
通过福尔克方法提取葡萄球菌脓肿发现，所有的杀葡萄球菌活性都存在于脂质部分。对脂质的进一步分离表明，杀菌活性存在于游离脂肪酸池中。从肠系膜或附睾脂肪组织中类似提取的脂质，无论在激活之前还是之后，都不具有可比的活性。肉豆蔻酸、棕榈酸、棕榈油酸、亚油酸和油酸，以及溶血卵磷脂，也未能表现出从脓肿匀浆中获得的脂肪酸部分的特性。这些发现表明，杀葡萄球菌脂肪酸不是一种常见的宿主脂质。
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