贝司他汀对膀胱癌患者E玫瑰花结形成的恢复作用。
Restoration of E-rosette formation by bestatin in patients with bladder cancer.
作者信息
Yokoyama H, Umeda T, Kobayashi K, Akaza H, Niijima T
出版信息
J Cancer Res Clin Oncol. 1980;98(2):195-201. doi: 10.1007/BF00405963.
Incubation of peripheral blood lymphocytes from patients with bladder cancer in bestatin (specific inhibitor of aminopeptidase B and leucine aminopeptidase) solution resulted in a significant increase in the proportion of E-rosette-forming lymphocytes. The increase in the proportion of E-rosette-forming lymphocytes was abolished after reincubation with 100% autochthonous serum. The fraction of E-rosette-forming lymphocytes from patients with bladder cancer which had restored receptors for sheep erythrocytes (SRBC) by incubation with bestatin also expressed receptors for the Fc portion of IgG and IgM. The proportion of EAC-forming lymphocytes remained unchanged after the incubation with bestatin. When 600 mg of bestatin was administered for 1 day to patients with bladder cancer, restorative effect on the proportion of E-rosette forming lymphocytes was also demonstrated. The proportion of EAC-forming lymphocytes, however, did not change significantly.
将膀胱癌患者的外周血淋巴细胞置于贝司他汀（氨肽酶B和亮氨酸氨肽酶的特异性抑制剂）溶液中孵育，结果显示形成E花环的淋巴细胞比例显著增加。用100%自身血清再次孵育后，形成E花环的淋巴细胞比例增加的现象消失。通过与贝司他汀孵育而恢复了对绵羊红细胞（SRBC）受体的膀胱癌患者中，形成E花环的淋巴细胞部分也表达了IgG和IgM的Fc部分受体。与贝司他汀孵育后，形成EAC的淋巴细胞比例保持不变。当给膀胱癌患者每日服用600 mg贝司他汀，持续1天时，对形成E花环的淋巴细胞比例也显示出恢复作用。然而，形成EAC的淋巴细胞比例没有显著变化。
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