通过高效液相色谱法测定药物-蛋白质结合参数的保留数据方法。
Retention data methods for the determination of drug-protein binding parameters by high-performance liquid chromatography.
作者信息
Sebille B, Thuaud N, Tillement J P
出版信息
J Chromatogr. 1981 Jan 16;204:285-91. doi: 10.1016/s0021-9673(00)81670-2.
PMID:7217256
Abstract
The binding to human serum albumin of some drugs (warfarin, furosemide and phenylbutazone) has been studied by high-performance liquid chromatography. Two methods have been used and compared, based on the measurement of the ligand retention volume under different conditions. The obtained total affinities of the drugs for the protein are in accordance with our previous results. The equilibrium saturation method leads easily to ni and Ki parameters from the retention volume of the ligand.
摘要
已通过高效液相色谱法研究了某些药物（华法林、呋塞米和保泰松）与人血清白蛋白的结合情况。基于在不同条件下配体保留体积的测量，使用并比较了两种方法。所获得的药物与蛋白质的总亲和力与我们之前的结果一致。平衡饱和法可根据配体的保留体积轻松得出ni和Ki参数。
相似文献
1
Retention data methods for the determination of drug-protein binding parameters by high-performance liquid chromatography.通过高效液相色谱法测定药物-蛋白质结合参数的保留数据方法。
J Chromatogr. 1981 Jan 16;204:285-91. doi: 10.1016/s0021-9673(00)81670-2.
2
Protein-binding high-performance frontal analysis of (R)- and (S)-warfarin on HSA with and without phenylbutazone.在有和没有苯基丁氮酮的情况下，对人血清白蛋白上的（R）-和（S）-华法林进行蛋白质结合高效前沿分析
J Pharm Sci. 1997 Jan;86(1):120-5. doi: 10.1021/js9600134.
3
Spectrophotofluorometric evidence of negatively cooperative binding of warfarin and phenylbutazone to human serum albumin.华法林和保泰松与人类血清白蛋白负协同结合的分光光度荧光法证据。
Life Sci. 1980 Jan 21;26(3):173-9. doi: 10.1016/0024-3205(80)90291-x.
4
Cooperative interaction of warfarin and phenylbutazone with human serum albumin.华法林和保泰松与人血清白蛋白的协同相互作用。
Biochem Pharmacol. 1981 Jun 1;30(11):1169-73. doi: 10.1016/0006-2952(81)90293-8.
5
Vacancy affinity capillary electrophoresis to study competitive protein-drug binding.空位亲和毛细管电泳法研究蛋白质-药物的竞争性结合
J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):205-10. doi: 10.1016/s0378-4347(98)00127-3.
6
Binding of certain acidic drugs to human albumin: theoretical and practical estimation of fundamental parameters.某些酸性药物与人血清白蛋白的结合：基本参数的理论与实际估算
Eur J Clin Pharmacol. 1974 Jul 26;7(4):307-13. doi: 10.1007/BF00560349.
7
Study of binding of low-molecular-weight ligand to biological macromolecules by high-performance liquid chromatography. Evaluation of binding parameters for two drugs bound to human serum albumin.用高效液相色谱法研究低分子量配体与生物大分子的结合。评估两种药物与人血清白蛋白结合的结合参数。
J Chromatogr. 1978 Dec 21;167:159-70. doi: 10.1016/s0021-9673(00)91155-5.
8
Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase.基于人血清白蛋白的固定相上，通过高效液相亲和色谱法揭示辛酸对药物与人血清白蛋白的变构和竞争性置换作用。
J Chromatogr. 1992 Jun 10;577(2):305-15. doi: 10.1016/0378-4347(92)80252-l.
9
Warfarin metabolites: stereochemical aspects of protein binding and displacement by phenylbutazone.华法林代谢产物：蛋白质结合的立体化学方面以及苯基丁氮酮对其的置换作用
Chirality. 1993;5(8):610-5. doi: 10.1002/chir.530050808.
10
Comparison of drug binding interactions on human, rat and rabbit serum albumin using high-performance displacement chromatography.使用高效置换色谱法比较药物与人、大鼠和兔血清白蛋白的结合相互作用。
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Nov;112(3):257-66. doi: 10.1016/0742-8413(95)02019-5.
引用本文的文献
1
CHROMATOGRAPHIC ANALYSIS OF DRUG INTERACTIONS IN THE SERUM PROTEOME.血清蛋白质组中药物相互作用的色谱分析
Anal Methods. 2011 Jul 1;3(7). doi: 10.1039/C1AY05068K.
Zotero 插件