采用火焰离子化检测法对血清中马普替林治疗浓度进行气相色谱分析。
Gas chromatographic analysis of therapeutic concentrations of maprotiline in serum, using flame-ionization detection.
作者信息
Kärkkäinen S, Seppälä E
出版信息
J Chromatogr. 1980 Dec 12;221(2):319-26. doi: 10.1016/s0378-4347(00)84317-0.
For the measurement of the tetracyclic antidepressant maprotiline in human serum, a gas chromatographic method with flame-ionization detection has been developed. The assay specifications obtained are as follows: a precision (C.V) of 3.5-6.4%, and a relative recovery of 97-109% using amitriptyline as internal standard. The sensitivity of the assay from serum was 40 nmol/l. The applicability of the method has been shown by measuring steady-state serum levels of five inpatients. The steady-state serum levels of maprotiline given at a daily dosage of 75 mg varied from 272 to 570 nmol/l.
为测定人血清中的四环类抗抑郁药马普替林，已开发出一种带火焰离子化检测的气相色谱法。获得的分析规格如下：精密度（变异系数）为3.5 - 6.4%，以阿米替林为内标时相对回收率为97 - 109%。该血清分析方法的灵敏度为40 nmol/l。通过测定5名住院患者的稳态血清水平证明了该方法的适用性。每日剂量75 mg的马普替林稳态血清水平在272至570 nmol/l之间变化。
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