Kärkkäinen S, Seppälä E
J Chromatogr. 1980 Dec 12;221(2):319-26. doi: 10.1016/s0378-4347(00)84317-0.
For the measurement of the tetracyclic antidepressant maprotiline in human serum, a gas chromatographic method with flame-ionization detection has been developed. The assay specifications obtained are as follows: a precision (C.V) of 3.5-6.4%, and a relative recovery of 97-109% using amitriptyline as internal standard. The sensitivity of the assay from serum was 40 nmol/l. The applicability of the method has been shown by measuring steady-state serum levels of five inpatients. The steady-state serum levels of maprotiline given at a daily dosage of 75 mg varied from 272 to 570 nmol/l.
为测定人血清中的四环类抗抑郁药马普替林，已开发出一种带火焰离子化检测的气相色谱法。获得的分析规格如下：精密度（变异系数）为3.5 - 6.4%，以阿米替林为内标时相对回收率为97 - 109%。该血清分析方法的灵敏度为40 nmol/l。通过测定5名住院患者的稳态血清水平证明了该方法的适用性。每日剂量75 mg的马普替林稳态血清水平在272至570 nmol/l之间变化。
