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病灶内注射皮质类固醇

Intralesional corticosteroids.

作者信息

Callen J P

出版信息

J Am Acad Dermatol. 1981 Feb;4(2):149-51. doi: 10.1016/s0190-9622(81)70017-3.

DOI:10.1016/s0190-9622(81)70017-3
PMID:7217384
Abstract

Intralesional corticosteroids are commonly used in clinical dermatology. They are an adjunct to topicals and a possible substitution for systemic corticosteroids. Intralesional corticosteroids can be injected via a syringe and needle or with a Dermo-Jet. Although multiple preparations are available, the triamcinolones have more acceptable physical characteristics. Systemic absorption and consequent adverse effects are rarely a problem because of low dosage administered. Local adverse effects (the most prominent of which is atrophy) depend on the strength of the preparation, the quantity used, the area of the body, and the skin condition being treated.

摘要

皮损内注射皮质类固醇激素在临床皮肤科中常用。它们是外用药物的辅助手段,也是全身用皮质类固醇激素的一种可能替代物。皮损内注射皮质类固醇激素可通过注射器和针头或使用皮肤喷射器进行注射。尽管有多种制剂可供使用,但曲安奈德类药物具有更易接受的物理特性。由于给药剂量低,全身吸收及随之而来的不良反应很少成为问题。局部不良反应(其中最突出的是萎缩)取决于制剂的强度、使用量、身体部位以及所治疗的皮肤状况。

相似文献

1
Intralesional corticosteroids.病灶内注射皮质类固醇
J Am Acad Dermatol. 1981 Feb;4(2):149-51. doi: 10.1016/s0190-9622(81)70017-3.
2
Benefits and risks of intralesional corticosteroid injection in the treatment of dermatological diseases.皮损内注射皮质类固醇治疗皮肤病的益处与风险。
Clin Exp Dermatol. 1995 Sep;20(5):363-70. doi: 10.1111/j.1365-2230.1995.tb01351.x.
3
The use and abuse of topical corticosteroids in dermatology.皮肤科中局部用皮质类固醇的使用与滥用
Scott Med J. 1980 Oct;25(4):287-91. doi: 10.1177/003693308002500408.
4
Adverse effects of corticosteroids.皮质类固醇的不良反应。
Cutis. 1979 Apr;23(4):477-87.
5
Letter: Evaluation of atrophy production and vasoconstrictor potency in humans following intradermally injected corticosteroids.信函:皮内注射皮质类固醇后人体萎缩产生情况及血管收缩效能评估
J Invest Dermatol. 1975 Apr;64(4):277. doi: 10.1111/1523-1747.ep12512075.
6
Treatment of local, persistent cutaneous atrophy following corticosteroid injection with normal saline infiltration.用生理盐水浸润治疗皮质类固醇注射后局部持续性皮肤萎缩。
Dermatol Surg. 2005 Oct;31(10):1340-3. doi: 10.1111/j.1524-4725.2005.31216.
7
Local subcutaneous atrophy after corticosteroid injection.皮质类固醇注射后局部皮下萎缩
Postgrad Med. 1986 Sep 15;80(4):159-60. doi: 10.1080/00325481.1986.11699543.
8
Absorption of corticosteroids through the skin.皮质类固醇通过皮肤的吸收。
Lancet. 1966 Feb 5;1(7432):306.
9
Topical corticosteroids in dermatology.皮肤科中的外用皮质类固醇激素。
J Drugs Dermatol. 2009 Dec;8(12):1093-105.
10
Percutaneous absorption of corticosteroids: systemic effects.
N Engl J Med. 1965 Oct 14;273(16):831-40. doi: 10.1056/NEJM196510142731601.

引用本文的文献

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Local Corticosteroids for Alopecia Areata: A Narrative Review.局部使用皮质类固醇治疗斑秃:一项叙述性综述
Dermatol Ther (Heidelb). 2025 May 5. doi: 10.1007/s13555-025-01421-2.
2
Intralesional Corticosteroid Administration in the Treatment of Keloids: A Scoping Review on Injection Methods.瘢痕内皮质类固醇注射治疗:注射方法的范围综述。
Dermatology. 2023;239(3):462-477. doi: 10.1159/000529220. Epub 2023 Jan 19.
3
Intralesional Agents in Dermatology: Pros and Cons.皮肤科皮损内注射药物:利弊
J Cutan Aesthet Surg. 2021 Jul-Sep;14(3):285-295. doi: 10.4103/JCAS.JCAS_109_20.
4
Current trends in needle-free jet injection: an update.无针喷射注射的当前趋势:最新进展
Clin Cosmet Investig Dermatol. 2018 May 1;11:231-238. doi: 10.2147/CCID.S162724. eCollection 2018.
5
Management of extrapulmonary sarcoidosis: challenges and solutions.肺外结节病的管理:挑战与解决方案
Ther Clin Risk Manag. 2016 Nov 7;12:1623-1634. doi: 10.2147/TCRM.S74476. eCollection 2016.
6
[Sarcoidosis : Organ involvement, diagnosis, current treatment].[结节病:器官受累、诊断及当前治疗]
Hautarzt. 2015 Jul;66(7):549-63. doi: 10.1007/s00105-015-3646-5.
7
Iris depigmentation: an unusual complication of intralesional corticosteroid injection for capillary hemangioma.虹膜色素脱失:局部注射皮质类固醇治疗毛细血管瘤的一种罕见并发症。
Middle East Afr J Ophthalmol. 2010 Jan;17(1):100-2. doi: 10.4103/0974-9233.61226.