Shibasaki H, McDonald W I, Kuroiwa Y
J Neurol Sci. 1981 Feb;49(2):253-71. doi: 10.1016/0022-510x(81)90083-6.
Two hundred and four consecutive British cases and 60 consecutive Japanese cases of probable (clinically definite) multiple sclerosis, seen at The National Hospital for Nervous Disease, Maida Vale, London and at Kyushu University Hospital, Fukuoka, Japan, respectively, over a defined period of time, were reviewed retrospectively by the same neurologist, using the same diagnostic criteria and the same method of analysis. The clinical pictures in the present 2 series were in many respects similar to each other and to that of other reported series. Some significant differences were found, however: there was (1) a greater incidence of visual loss at the onset of illness, (2) more frequent and severe involvement of spinal cord and brainstem during the course of illness, as judged clinically, and (3) more severe visual disability in the Japanese series as compared with the British series.
伦敦麦达维尔国家神经疾病医院和日本福冈九州大学医院分别在特定时间段内连续收治的204例英国疑似（临床确诊）多发性硬化症病例和60例日本疑似（临床确诊）多发性硬化症病例，由同一位神经科医生进行回顾性研究，采用相同的诊断标准和相同的分析方法。这两个系列病例的临床表现在许多方面彼此相似，也与其他已报道系列的表现相似。然而，也发现了一些显著差异：（1）发病时视力丧失的发生率更高；（2）从临床判断，病程中脊髓和脑干受累更频繁、更严重；（3）与英国系列相比，日本系列的视力残疾更严重。
