Shibasaki H, Kuroiwa Y
J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1139-43. doi: 10.1136/jnnp.45.12.1139.
Forty-seven Japanese patients with multiple sclerosis, 29 probable (clinically definite) and 18 possible, were studied by black-and-white checkerboard pattern reversal visual evoked potential and were compared with a control group of 20 healthy young adults. The major positive peak (P100) was found to be abnormal in 70% of all cases, 90% of probable cases and 39% of possible cases. P100 was delayed in 38% of all cases and was absent in 23% of all cases. None of the eyes showing a flat pattern response was in the acute stage of optic neuritis. The percentage of cases with no response (23% of all cases) was greater than any of the previously reported series from Western countries, substantiating the previously reported clinical features of oriental multiple sclerosis. The pattern response was absent only when testing eyes with severe visual impairment, whereas delayed latency of P100 was seen regardless of the severity of visual impairment, suggesting the usefulness of P100 latency for detecting subclinical optic nerve lesions.
对47例日本多发性硬化症患者进行了研究，其中29例可能（临床确诊），18例可能疑似，采用黑白棋盘格模式反转视觉诱发电位进行检测，并与20名健康年轻成年人组成的对照组进行比较。结果发现，所有病例中有70%的主要正波峰（P100）异常，可能病例中有90%，可能疑似病例中有39%。所有病例中有38%的P100延迟，23%的病例中P100缺失。所有出现平坦图形反应的眼睛均不在视神经炎急性期。无反应病例的百分比（占所有病例的23%）高于西方国家此前报道的任何系列，证实了此前报道的东方多发性硬化症的临床特征。仅在检测视力严重受损的眼睛时图形反应缺失，而无论视力损害的严重程度如何，均可见P100潜伏期延迟，这表明P100潜伏期对于检测亚临床视神经病变有用。
