Tomlinson B E, Irving D, Blessed G
J Neurol Sci. 1981 Mar;49(3):419-28. doi: 10.1016/0022-510x(81)90031-9.
Sample counts of the pigmented cells of the locus coeruleus (LC) were performed in 10 middle-aged and 15 old people considered to be intellectually well preserved and in 15 cases of senile dementia of Alzheimer type (SDAT). Evidence of a gradual loss of neurons from early middle to old age was found in the control group. In the cases of SDAT 7 counts were within the lower range for the controls but 8 had fewer neurons than any control recorded and the mean count for all the SDAT cases was significantly less than that of the older controls. Some evidence exists that the more severe cases of SDAT in terms of neocortical plaque formation have the greatest loss of LC neurons.
对10名被认为智力保存良好的中年人和15名老年人以及15例阿尔茨海默型老年痴呆症（SDAT）患者的蓝斑（LC）色素细胞进行了样本计数。在对照组中发现了从中年早期到老年神经元逐渐丢失的证据。在SDAT病例中，7例计数处于对照组的较低范围，但8例的神经元数量比所记录的任何对照组都少，并且所有SDAT病例的平均计数显著低于老年对照组。有证据表明，就新皮质斑块形成而言，SDAT病情越严重，LC神经元丢失就越严重。
