Takeuchi A, Kobayashi K, Mori M, Mizushima Y
J Rheumatol. 1981 Jan-Feb;8(1):40-4.
We previously reported that the chemotactic response of granulocytes from the patients with Behcet's disease is higher than normal neutrophils. In this study we examined the mechanism by which neutrophils from the patients with Behcet's disease were hyperchemotactic. Normal and patients' leukocytes were disrupted in hypertonic sucrose, sonicated and the supernate was examined. The extracts from the disrupted Behcet's neutrophils increased the normal granulocyte response to the chemotactic stimulus more strongly than extracts from normal cells. This active substance was localized mainly in the cytoplasmic fraction of leukocytes. The fact that Behcet's neutrophils have a higher concentration of the cytoplasmic activator might play an important role in the pathogenesis of hyperchemotaxis.
我们之前报道过，白塞病患者的粒细胞趋化反应高于正常中性粒细胞。在本研究中，我们研究了白塞病患者中性粒细胞超趋化的机制。将正常和患者的白细胞在高渗蔗糖中破碎，超声处理后检查上清液。与正常细胞提取物相比，破碎的白塞病中性粒细胞提取物更强烈地增强了正常粒细胞对趋化刺激的反应。这种活性物质主要定位于白细胞的细胞质部分。白塞病中性粒细胞细胞质激活剂浓度较高这一事实可能在超趋化的发病机制中起重要作用。
