通过123I-马尿酸肾图评估肾血浆总流量和分侧肾血浆流量。

Assessment of total and divided renal plasma flow by 123I-hippuran renography.

作者信息

Mackay A, Eadie A S, Cumming A M, Graham A G, Adams F G, Horton P W

出版信息

Kidney Int. 1981 Jan;19(1):49-57. doi: 10.1038/ki.1981.6.

DOI:10.1038/ki.1981.6

Abstract

We studied 23 patients with suspected renal hypertension, including 12 with renal artery stenosis, or occlusion. Total effective renal plasma flow (ERPF) was measured in all patients by conventional p-aminohippurate (PAH) clearance and by 123I-hippuran clearance performed on the same day. A close correlation between the two techniques was obtained (r = 0.87, P less than 0.001) with the latter technique underestimating the former by a mean ratio of 0.89:1.00. We describe a technique for deriving ERPF for individual kidneys by 123I-hippuran renography, and the data obtained by this method correlate well with data obtained from bilateral ureteric catheterization studies (r = 0.076, P less than 0.001 for both affected and unaffected sides) in 17 patients. The renographic technique is particularly accurate in quantitating ERPF in the 12 patients with renal artery stenosis, and is recommended as the investigation of choice in the assessment of ERPF in patients with this condition.

摘要

我们研究了23例疑似肾性高血压患者，其中12例存在肾动脉狭窄或闭塞。所有患者均通过传统的对氨基马尿酸（PAH）清除率以及同日进行的123I-马尿酸清除率来测量总有效肾血浆流量（ERPF）。两种技术之间存在密切相关性（r = 0.87，P < 0.001），后一种技术低估前一种技术的平均比例为0.89:1.00。我们描述了一种通过123I-马尿酸肾图来推导单个肾脏ERPF的技术，并且该方法获得的数据与17例患者双侧输尿管插管研究获得的数据具有良好的相关性（患侧和未患侧的r均为0.076，P < 0.001）。肾图技术在定量12例肾动脉狭窄患者的ERPF方面特别准确，被推荐作为评估此类患者ERPF的首选检查方法。