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豚鼠主要组织相容性复合体中的基因影响对蛇形毛圆线虫感染的易感性。

Genes within the major histocompatibility complex of the guinea pig influence susceptibility to Trichostrongylus colubriformis infection.

作者信息

Geczy A F, Rothwell T L

出版信息

Parasitology. 1981 Apr;82(Pt 2):281-6. doi: 10.1017/s0031182000057024.

DOI:10.1017/s0031182000057024
PMID:7220089
Abstract

The influence of genes in the major histocompatibility complex (MHC) of the guinea pig on the susceptibility to infection with the parasitic nematode Trichostrongylus colubriformis was investigated. Back-cross analysis of 2 lines of guinea pigs suggests that genes that map in or near the I region of the guinea pig MHC influence susceptibility to infection by the parasite. However, other genes, possibly not linked to the guinea pig MHC, may also be required for the full expression of susceptibility.

摘要

研究了豚鼠主要组织相容性复合体（MHC）中的基因对感染寄生线虫蛇形毛圆线虫易感性的影响。对两系豚鼠的回交分析表明，位于豚鼠MHC I区或其附近的基因影响对该寄生虫感染的易感性。然而，完全表达易感性可能还需要其他基因，这些基因可能与豚鼠MHC不连锁。

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