Attia M A, el-Sourady H A, el-Shanawany S M
Pharmazie. 1985 Sep;40(9):629-31.
The stability of chlortetracycline hydrochloride at 25 and 35 degrees C in absorption base with and without antioxidant decreased during storage for 12 months, while, in water-in-oil emulsion base the medicament was more stable than in oil-in-water emulsion ointment bases. Chloramphenicol was more stable in the absorption base that contained lanolin than in the base which contained cetyl alcohol. Chloramphenicol was more stable in oil-in-water than in water-in-oil emulsion bases. The decomposition rate constant of chlortetracycline hydrochloride and chloramphenicol followed first order kinetics, when the stability study was carried out at 25 and 35 degrees C.
盐酸金霉素在25℃和35℃下，于含和不含抗氧化剂的吸收性基质中储存12个月期间稳定性下降，而在油包水型乳剂基质中该药物比在水包油型乳剂软膏基质中更稳定。氯霉素在含羊毛脂的吸收性基质中比在含十六醇的基质中更稳定。氯霉素在水包油型乳剂中比在油包水型乳剂基质中更稳定。当在25℃和35℃进行稳定性研究时，盐酸金霉素和氯霉素的分解速率常数符合一级动力学。
