Ghanem A H, El-Sabbagh H M, El-Helw A M
Pharmazie. 1978 Jul;33(7):443-5.
1, 3 and 5% water, ethyl alcohol, glycerol and propylene glycol were incorporated into oleaginous, absorption, emulsion (O/W and W/O) and water-soluble ointment bases (resp.) containing 5% of chloramphenicol and diffusion rate via the dialysis method was measured for 2 h. The rate of release was found to be greater from water-soluble bases than from the other bases, since rates from oleaginous, absorption and W/O emulsion bases were found to be the least in this respect. The effect of liquids added to these bases on drug release was found to be less pronounced than that obtained with water-soluble and O/W emulsion bases. For O/W emulsion bases the addition of ethyl alcohol increased the release of chloramphenicol as its concentration was increased. Propylene glycol increased the release at a concentration of 3%, but higher concentration produced opposite results. Glycerol was found to have a little effect in 5% concentration, but it increased the release as the concentration dropped to 3% concentration.
将1%、3%和5%的水、乙醇、甘油和丙二醇分别加入含有5%氯霉素的油性、吸收性、乳剂（水包油型和油包水型）及水溶性软膏基质中，通过透析法测定2小时内的扩散速率。发现水溶性基质中的释放速率高于其他基质，因为在这方面油性、吸收性和油包水乳剂基质的速率最低。发现添加到这些基质中的液体对药物释放的影响不如水溶性和水包油乳剂基质明显。对于水包油乳剂基质，随着乙醇浓度的增加，氯霉素的释放量增加。丙二醇在浓度为3%时增加了释放量，但更高浓度时产生相反的结果。发现甘油在5%浓度时影响较小，但当浓度降至3%时释放量增加。
